Youth antisocial behavior is an important public health concern impacting perpetrators, victims, and society as a whole. Although a risk factor approach has helped inform interventions for antisocial youth, these interventions work only for some youth in some contexts. Thus more basic research is needed to highlight when, for whom and how risk affects psychopathology and resilience. I will review work that we’ve done using both neurogenetics and developmental psychopathology approaches to understand these complex behaviors with a focus on mechanisms linking risk to outcomes and identifying interplay between experience and biology to demonstrate how neurogenetic approaches can help inform our understanding of youth antisocial behavior.